Successive Euploid Single Embryo Transfers

Sometimes we wonder if the pregnancy rates are still good after several unsuccessful euploid single embryo transfers. Data from our center and that of a 2021 study from the Reproductive Medicine Associates of New Jersey (Basking Ridge, New Jersey) seems to show only a slight decrease in rate of fetal heartbeat per euploid single embryo transfer from the first to the third transfer. The decrease is approximately 10-12% from the first to the third euploid single embryo transfer.

Data from Institute for Reproductive Health (data from 2023 to 2026):

There are good rates of fetal heartbeat at our center even after several unsuccessful single euploid embryo transfers. Rates of fetal heartbeat were 54% for the first, 48% for the second, 42% for the third, and 47% for the fourth/fifth successive euploid single embryo transfers. This data is from 1/1/2023 to 4/2/26.

Data from Reproductive Medicine Associates of New Jersey (data from 2012 to 2018, published in 2021):

Rates of fetal heatbeat were 70% for the first, 60% for the second, and 60% for the third successive euploid single embryo transfers.

Pirtea P, De Ziegler D, Tao X, Sun L, Zhan Y, Ayoubi JM, Seli E, Franasiak JM, Scott Jr RT. Rate of true recurrent implantation failure is low: results of three successive frozen euploid single embryo transfers. Fertility and sterility. 2021 Jan 1;115(1):45-53.